Becn1^tm1.1Bflu
Targeted Allele Detail

Summary

• Symbol: Becn1^tm1.1Bflu
• Name: beclin 1, autophagy related; targeted mutation 1.1, Binfeng Lu
• MGI ID: MGI:5527250
• Synonyms: BECN1 fl
• Gene: Becn1 Location: Chr11:101179084-101193112 bp, - strand Genetic Position: Chr11, 64.58 cM, cytoband D
• Alliance: Becn1^tm1.1Bflu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203090
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted usptream of eoxn 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. (J:203090)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Becn1 Mutation: 36 strains or lines available

References

• Original: J:203090 Kovacs JR, et al., Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ. 2012 Jan;19(1):144-52
• All: 3 reference(s)