Krt1c^tm1Tmm
Targeted Allele Detail

Summary

• Symbol: Krt1c^tm1Tmm
• Name: keratin 1 complex; targeted mutation 1, Thomas M Magin
• MGI ID: MGI:5527256
• Gene: Krt1c Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199528
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The mutagenic insertion and chromosome engineering resource (MICER) 5' hprt vector clone MHPN117k13 was used to insert a loxP site at the 5' end of the type II keratin cluster (Krt1c) upstream of Krt80 (between Krt80 and Krt7). This clone contains an insert of 6 kb spanning 101,202,450-101,208,417 bp on chromosome 15 (genome assembly unknown), and includes the tyrosinase (Tyr) coat color gene, an HPRT mini-gene, a loxP site, and a neomycin resistance gene cassette. (J:153804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt1c Mutation: 0 strains or lines available

References

• Original: J:153804 Vijayaraj P, et al., Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J Cell Biol. 2009 Oct 19;187(2):175-84
• All: 5 reference(s)