Tg(MMTV-ERBB2)5Erick
Transgene Detail

Summary

• Symbol: Tg(MMTV-ERBB2)5Erick
• Name: transgene insertion 5, Sharon Erickson
• MGI ID: MGI:5527316
• Synonyms: Fo5, MMTV.f.huHER2 #5, MMTV-HER2
• Transgene: Tg(MMTV-ERBB2)5Erick Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Tg(MMTV-ERBB2)5Erick page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-ERBB2)5Erick expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene contains the MMTV promoter, the 3' of human growth hormone exons 4 and 5, and the human ERBB2 cDNA with the ATG removed. The transgene integrated at a single site on chromosome 6 and quantitative PCR analysis suggests a transgene copy number of 30-50. (J:90202)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-ERBB2)5Erick

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:90202 Finkle D, et al., HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. Clin Cancer Res. 2004 Apr 1;10(7):2499-511
• All: 6 reference(s)