Col1a1^{tm1(tetO-EML4/ALK)Kkw}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-EML4/ALK)Kkw}
• Name: collagen, type I, alpha 1; targeted mutation 1, Kwok-Kin Wong
• MGI ID: MGI:5527336
• Synonyms: EML4-ALK
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-EML4/ALK)Kkw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166724
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-EML4/ALK)Kkw} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

  human

  EML4 (27436)

  Eml4	(MGI:1926048)

• Col1a1^{tm1(tetO-EML4/ALK)Kkw} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details: The human EML4 and ALK variant 1 fusion under the control of the doxycycline inducible Tet-op promoter was knocked into the locus. (J:166724)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 163 strains or lines available

References

• Original: J:166724 Chen Z, et al., Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene. Cancer Res. 2010 Dec 1;70(23):9827-9836
• All: 4 reference(s)