Kidins220^tm1.2Fces
Targeted Allele Detail

Summary

• Symbol: Kidins220^tm1.2Fces
• Name: kinase D-interacting substrate 220; targeted mutation 1.2, Fabrizia Cesca
• MGI ID: MGI:5527339
• Gene: Kidins220 Location: Chr12:25024924-25113151 bp, + strand Genetic Position: Chr12, 8.54 cM
• Alliance: Kidins220^tm1.2Fces page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203073
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed corresponding cDNA with a polyadenylation sequence was inserted upstream of exon 16. An IRES, lacZ and polyadenylation sequence followed by an FRT-flanked neomycin resistance cassette replaced exon 17. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the cDNA. Western blot analysis confirmed the absence of protein expression in E18 embryos. (J:203073)

Expression

In Mice Carrying this Mutation:	74 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kidins220 Mutation: 79 strains or lines available

References

• Original: J:203073 Cesca F, et al., Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012 Feb;19(2):194-208
• All: 8 reference(s)