Bcl2l11^tm5Boul
Targeted Allele Detail

Summary

• Symbol: Bcl2l11^tm5Boul
• Name: BCL2 like 11; targeted mutation 5, Philippe Bouillet
• MGI ID: MGI:5527368
• Synonyms: BimEL-only
• Gene: Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
• Alliance: Bcl2l11^tm5Boul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Nucleotide substitutions (AGGT to GGGG) at the exon 2 and 3 splice acceptor site abolishes production of the isoform resulting from skipping of exon 3. Only the EL isoform is produced from this allele. (J:203181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l11 Mutation: 36 strains or lines available

References

• Original: J:203181 Clybouw C, et al., Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo. Cell Death Differ. 2012 Jun;19(6):1060-8
• All: 1 reference(s)