Tg(Aire-cre/ERT2*)1Mand
Transgene Detail

Summary

• Symbol: Tg(Aire-cre/ERT2*)1Mand
• Name: transgene insertion 1, Mark Anderson
• MGI ID: MGI:5527371
• Synonyms: Aire-Cre
• Transgene: Tg(Aire-cre/ERT2*)1Mand Location: unknown
• Alliance: Tg(Aire-cre/ERT2*)1Mand page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Aire-cre/ERT2*)1Mand expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Aire

• Mutation details: A targeting construct was used for recombineering to insert an ERT2-cre-ERT2 sequence (cre fused to two mutated human estrogen receptor ligand-binding domains) into a BAC containing the Aire locus. The inducible cre cassette replaced exon 2 of Aire. The resulting linearized BAC was injected into fertilized FVB oocytes. Founder and line number information is not available. (J:203553)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (species not specified) Summary of all recombinase alleles driven by Aire. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:203553 Metzger TC, et al., Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17;5(1):166-79
• All: 4 reference(s)