Bok^tm1.1Ast
Targeted Allele Detail

Summary

• Symbol: Bok^tm1.1Ast
• Name: BCL2-related ovarian killer; targeted mutation 1.1, Andreas Strasser
• MGI ID: MGI:5527387
• Gene: Bok Location: Chr1:93613382-93623486 bp, + strand Genetic Position: Chr1, 47.28 cM
• Alliance: Bok^tm1.1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203179
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1b. An FRT- and loxP-flanked hygromycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 1b, exon 2 and the hygromycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the uterus, rectum, colon, placenta and spleen. (J:203179)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bok Mutation: 22 strains or lines available

References

• Original: J:203179 Ke F, et al., BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. Cell Death Differ. 2012 Jun;19(6):915-25
• All: 11 reference(s)