Tal1^tm1.1Bgo
Targeted Allele Detail

Summary

• Symbol: Tal1^tm1.1Bgo
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 1.1, Berthold Gottgens
• MGI ID: MGI:5527393
• Synonyms: Scl^delta19
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^tm1.1Bgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203178
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed hygromycin resistance cassette replaced a 2.5 kb region containing +18 and +19 elements that corresponds to the 3' stem cell enhancer. Cre-mediated recombination removed the hygromycin resistance cassette. (J:88180)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 33 strains or lines available

References

• Original: J:88180 Gottgens B, et al., The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 2004 Mar;24(5):1870-83
• All: 2 reference(s)