Dmrta2^tm1.1Fuma
Targeted Allele Detail

Summary

• Symbol: Dmrta2^tm1.1Fuma
• Name: doublesex and mab-3 related transcription factor like family A2; targeted mutation 1.1, Fumio Matsuzaki
• MGI ID: MGI:5527460
• Synonyms: Dmrta2^flox
• Gene: Dmrta2 Location: Chr4:109835250-109840884 bp, + strand Genetic Position: Chr4, 51.37 cM
• Alliance: Dmrta2^tm1.1Fuma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203109
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:203109)

Generation of the Dmrta2^tm1.1Fuma and Dmrta2^tm1.2Fuma alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmrta2 Mutation: 15 strains or lines available

References

• Original: J:203109 Konno D, et al., The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One. 2012;7(10):e46577
• All: 2 reference(s)