Flot2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Flot2^tm1Mak
• Name: flotillin 2; targeted mutation 1, Tak Mak
• MGI ID: MGI:5527543
• Gene: Flot2 Location: Chr11:77928757-77951260 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Flot2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203238
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3 through 10. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts, brain, spleen, heart and lung. (J:203238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flot2 Mutation: 38 strains or lines available

References

• Original: J:203238 Berger T, et al., Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene. 2013 Oct 10;32(41):4989-94
• All: 3 reference(s)