Tnfaip3^tm4.1Ama
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm4.1Ama
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 4.1, Averil Ma
• MGI ID: MGI:5528685
• Synonyms: Tnfaip3^ZF4
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm4.1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203160
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 7 was replaced with one in which nucleotide substitutions result in the amino acid susbtitutions of alanine for cysteine at positions 609 and 612 (C609A, C612A). This mutation disrupts the zinc finger 4-based E3 ligase and ubiquitin binding. Cre-mediated recombnation removed the floxed neomycin resistance cassette inserted downstream of the modified exon 7. (J:203160)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:203160 Lu TT, et al., Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 2013 May 23;38(5):896-905
• All: 3 reference(s)