Tg(Amh-SMAD2*)2Tkw
Transgene Detail
|
Symbol: |
Tg(Amh-SMAD2*)2Tkw |
Name: |
transgene insertion 2, Teresa K Woodruff |
MGI ID: |
MGI:5528705 |
Synonyms: |
MIS-Smad2-dn, Smad2-dn |
Transgene: |
Tg(Amh-SMAD2*)2Tkw Location: unknown
|
Alliance: |
Tg(Amh-SMAD2*)2Tkw page
|
|
|
Transgene Type: |
|
Transgenic (Dominant negative, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Amh-SMAD2*)2Tkw expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SMAD2 (4087) |
|
Expresses a a C-terminal truncation of the human SMAD2 protein |
|
|
|
Mutation details: This transgene consists of a mouse minimal Mullerian-inhibiting substance promoter (-180 bp), an epitope Flag tag, a C-terminal truncation of the human Smad2 gene resulting in a dominant negative effect, and a human GH polyadenylation sequence. The Amh promoter drives transgene expression in testicular Sertoli cells and ovarian granulosa cells. RT-PCR and immunolocalization confirmed expression of RNA and protein in ovaries. Three lines were generated: 1, 2, and 3, however line 1 was lost
(J:129226)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:129226 Bristol-Gould SK, et al., The development of a mouse model of ovarian endosalpingiosis. Endocrinology. 2005 Dec;146(12):5228-36 |
All: |
1 reference(s) |
|