Cacna1c^tm1.1Wac
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1.1Wac
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1.1, William A Catterall
• MGI ID: MGI:5528791
• Synonyms: STAA
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1.1Wac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations were introduced in exon 41 to express Ala in place of Ser1700 and Thr1704 in the alpha-1 subunit of Cav1.2. The neo cassette was removed by flp mediated recombination. The total number of Cav1.2 channels are reduced by approximately 12% in myocytes from homozygous mice compared with wild-type. (J:203057)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:203057 Fu Y, et al., Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. (Correction: PNAS March 11, 2014; v. 111(10):3895). Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19621-6
• All: 3 reference(s)