Tg(Tbx21-cre)1Dlc
Transgene Detail

Summary

• Symbol: Tg(Tbx21-cre)1Dlc
• Name: transgene insertion 1, Catherine Dulac
• MGI ID: MGI:5528860
• Synonyms: Tbet-cre
• Transgene: Tg(Tbx21-cre)1Dlc Location: unknown
• Alliance: Tg(Tbx21-cre)1Dlc page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tbx21-cre)1Dlc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx21 (MGI:1888984)

• Mutation details: Cre cDNA was inserted at the start ATG of the Tbx21 gene in a BAC (RP23-237M14). The recombined BAC was linearized and injected into B6/CBA oocytes. 14 animals were generated and one was determined to be positive for the Tbx21-cre transgene. The single founder line was analyzed by immunohistochemistry for cre protein. Strong expression was detected and reporter crosses displayed recombination in the mitral and external tufted layers of the main and accessory olfactory bulbs, with no other brain tissues showing recombination. Activity was also observed in the thymus, a known site of Tbx21 expression. (J:203355)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx21 (mouse) Summary of all recombinase alleles driven by Tbx21. Comparative matrix view of recombinase activities Alliance mouse Tbx21 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:203355 Haddad R, et al., Olfactory cortical neurons read out a relative time code in the olfactory bulb. Nat Neurosci. 2013 Jul;16(7):949-57
• All: 32 reference(s)