Xkr8^tm1.2Osa
Targeted Allele Detail

Summary

• Symbol: Xkr8^tm1.2Osa
• Name: X-linked Kx blood group related 8; targeted mutation 1.2, Shigekazu Nagata
• MGI ID: MGI:5528895
• Synonyms: Xkr8^-
• Gene: Xkr8 Location: Chr4:132452208-132459857 bp, - strand Genetic Position: Chr4, 65.81 cM
• Alliance: Xkr8^tm1.2Osa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199440
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked PGK-neo cassette followed by a loxP site was inserted in intron 3 while an additional loxP site was inserted upstream of exon 3. The selection cassette and exon 3 were subsequently excised from properly targeted mice by flp and cre recombinase expression. (J:199440)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Xkr8 Mutation: 17 strains or lines available

References

• Original: J:199440 Suzuki J, et al., Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science. 2013 Jul 26;341(6144):403-6
• All: 4 reference(s)