Mirc14^tm1.1Flv
Targeted Allele Detail

Summary

• Symbol: Mirc14^tm1.1Flv
• Name: microRNA cluster 14, including Mir181a-1 through Mir181b-1; targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:5528987
• Synonyms: miR-181a1/b1^flox
• Gene: Mirc14 Location: Chr1:137894193-137894456 bp Genetic Position: Chr1, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203157
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of Mir181a-1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of Mir181b-1. Flp-mediated recombination removed the neomycin resistance cassette and left the microRNAs floxed. (J:203157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc14 Mutation: 1 strain or line available

References

• Original: J:203157 Henao-Mejia J, et al., The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 2013 May 23;38(5):984-97
• All: 4 reference(s)