Mpp3^tm1.1Wij
Targeted Allele Detail

Summary

• Symbol: Mpp3^tm1.1Wij
• Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3); targeted mutation 1.1, Jan Wijnholds
• MGI ID: MGI:5529041
• Gene: Mpp3 Location: Chr11:101890478-101919287 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Mpp3^tm1.1Wij page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo selection cassette followed by a loxP site was inserted in intron 6. A second loxP site was inserted upstream of exon 3. The selection cassette was excised from properly targeted mice by expression of flp recombinase. This left exons 3 through 6 flanked by loxP sites. (J:198427)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpp3 Mutation: 44 strains or lines available

References

• Original: J:198427 Dudok JJ, et al., MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex. J Neurosci. 2013 May 8;33(19):8518-27
• All: 3 reference(s)