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Itgb1tm14.1Ref
Targeted Allele Detail
Summary
Symbol: Itgb1tm14.1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 14.1, Reinhard Fassler
MGI ID: MGI:5529145
Synonyms: beta1 Y795A
Gene: Itgb1  Location: Chr8:129412135-129459681 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Alliance: Itgb1tm14.1Ref page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185558
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitution(s) result(s) in the amino acid substitution of an alanine for tyrosine at position 795 (Y795A). Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:185558, J:203018)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  60 strains or lines available
References
Original:  J:185558 Bottcher RT, et al., Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol. 2012 Jun;14(6):584-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory