Itgb1^tm15.1Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm15.1Ref
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 15.1, Reinhard Fassler
• MGI ID: MGI:5529154
• Synonyms: beta1 Y783A
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm15.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution(s) result(s) in the amino acid substitution of alanine for tyrosine at position 783 (Y783A). Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:203018)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:203018 Meves A, et al., beta1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis. J Invest Dermatol. 2013 Dec;133(12):2722-31
• All: 1 reference(s)