Sod1^tm1Svb
Targeted Allele Detail

Summary

• Symbol: Sod1^tm1Svb
• Name: superoxide dismutase 1, soluble; targeted mutation 1, Susan V Brooks
• MGI ID: MGI:5529176
• Synonyms: Sod1^flox
• Gene: Sod1 Location: Chr16:90017650-90023221 bp, + strand Genetic Position: Chr16, 51.56 cM, cytoband B5-C3
• Alliance: Sod1^tm1Svb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. A second loxP site was inserted downstream of exon 4. (J:201098)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sod1 Mutation: 39 strains or lines available

References

• Original: J:201098 Zhang Y, et al., CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice. FASEB J. 2013 Sep;27(9):3536-48
• All: 4 reference(s)