Hamp/Hamp2^{tm1.1(HAMP)Bjs}
Targeted Allele Detail

Summary

• Symbol: Hamp/Hamp2^{tm1.1(HAMP)Bjs}
• Name: hepcidin antimicrobial peptide 2; targeted mutation 1.1, Barbra J Sasu
• MGI ID: MGI:5529332
• Synonyms: Hep2
• Gene: Hamp2 Location: Chr7:30621797-30623606 bp, - strand Genetic Position: Chr7, 19.27 cM
• Alliance: Hamp/Hamp2^{tm1.1(HAMP)Bjs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequences were replaced with the human HAMP sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:203898)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hamp2 Mutation: 7 strains or lines available

References

• Original: J:203898 Sasu BJ, et al., Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood. 2010 Apr 29;115(17):3616-24
• All: 2 reference(s)