Hat1^tm1Mrpa
Targeted Allele Detail

Summary

• Symbol: Hat1^tm1Mrpa
• Name: histone aminotransferase 1; targeted mutation 1, Mark R Parthun
• MGI ID: MGI:5529369
• Synonyms: Hat1^flox
• Gene: Hat1 Location: Chr2:71219604-71271966 bp, + strand Genetic Position: Chr2, 42.38 cM
• Alliance: Hat1^tm1Mrpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199077
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A targeting vector was designed to insert loxP site upstream of exon 3, and a frt-flanked neomycin resistance (neo) cassette followed by a single loxP site downstream of exon 3. (J:199077)

Generation of the Hat1^tm1Mrpa and Hat1^tm1.1Mrpa alleles

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ht1	Hat1^tm1Mrpa/Hat1^+	involves: C57BL/6

Phenotypes:

Affected Systems	ht1
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normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hat1 Mutation: 43 strains or lines available

References

• Original: J:199077 Nagarajan P, et al., Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. PLoS Genet. 2013 Jun;9(6):e1003518
• All: 1 reference(s)