Ccn1^tm3.1Lfl
Targeted Allele Detail

Summary

• Symbol: Ccn1^tm3.1Lfl
• Name: cellular communication network factor 1; targeted mutation 3.1, Lester F Lau
• MGI ID: MGI:5529625
• Synonyms: Ccn1^flox
• Gene: Ccn1 Location: Chr3:145352731-145355736 bp, - strand Genetic Position: Chr3, 70.18 cM
• Alliance: Ccn1^tm3.1Lfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204032
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin resistance cassette and left exons 2 and 3 floxed. (J:204032)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccn1 Mutation: 35 strains or lines available

References

• Original: J:204032 Kim KH, et al., Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol. 2013 May;33(10):2078-90
• All: 12 reference(s)