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Ass1tm1.2Ekoe
Targeted Allele Detail
Summary
Symbol: Ass1tm1.2Ekoe
Name: argininosuccinate synthetase 1; targeted mutation 1.2, Eleonore Kohler
MGI ID: MGI:5529836
Gene: Ass1  Location: Chr2:31360282-31410682 bp, + strand  Genetic Position: Chr2, 21.81 cM
Alliance: Ass1tm1.2Ekoe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203474
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 13. An additional loxP site was inserted downstream of exon 13. Flpe-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 13. (J:203474)
Generation of the Ass1tm1.1Ekoe and Ass1tm1.2Ekoe alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ass1 Mutation:  58 strains or lines available
References
Original:  J:203474 Marion V, et al., Hepatic adaptation compensates inactivation of intestinal arginine biosynthesis in suckling mice. PLoS One. 2013;8(6):e67021
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory