Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}
Targeted Allele Detail

Summary

• Symbol: Axin2^{tm1.1(cre/ERT2/tdTomato)Eem}
• Name: axin 2; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:5532194
• Synonyms: Axin2-CreERT2/tdT, Axin2^{tm1.1(cre/ERT2/tdTomato)Smr}
• Gene: Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
• Alliance: Axin2^{tm1.1(cre/ERT2/tdTomato)Eem} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Axin2^{tm1.1(cre/ERT2/tdTomato)Eem} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Axin2 (MGI:1270862)

• Mutation details: cDNA encoding cre/ERT2 fused with tandem dimer Tomato cDNA (tdTomato) and a human growth hormone intron and polyadenylation site was inserted into the Axin2 locus downstream of the translation initiation codon using homologous recombination in ES cells. The neo selection cassette was excised by crossing germline animals to Flp1-expressing mice. (J:204142)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Axin2 (mouse) Summary of all recombinase alleles driven by Axin2. Alliance mouse Axin2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin2 Mutation: 44 strains or lines available

References

• Original: J:204142 Choi YS, et al., Distinct Functions for Wnt/beta-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell. 2013 Dec 5;13(6):720-33
• All: 10 reference(s)