Itpr1^tm1.1Kmik
Targeted Allele Detail

Summary

• Symbol: Itpr1^tm1.1Kmik
• Name: inositol 1,4,5-trisphosphate receptor 1; targeted mutation 1.1, Katsuhiko Mikoshiba
• MGI ID: MGI:5532199
• Gene: Itpr1 Location: Chr6:108190057-108528070 bp, + strand Genetic Position: Chr6, 49.74 cM
• Alliance: Itpr1^tm1.1Kmik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199800
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin selection cassette was inserted into intron 2 and a third loxP site was inserted into intron 3. The selection cassette was then excised from properly targeted clones by cre expression. As a result, exon 3 was flanked by loxP sites. (J:199800)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Itpr1 Mutation: 184 strains or lines available

References

• Original: J:199800 Sugawara T, et al., Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice. J Neurosci. 2013 Jul 24;33(30):12186-96
• All: 4 reference(s)