Gtf2i^tm1Vcam
Targeted Allele Detail

Summary

• Symbol: Gtf2i^tm1Vcam
• Name: general transcription factor II I; targeted mutation 1, Victoria Campuzano
• MGI ID: MGI:5532204
• Synonyms: Gtf2i^deltaexon2
• Gene: Gtf2i Location: Chr5:134266688-134343614 bp, - strand Genetic Position: Chr5, 74.48 cM
• Alliance: Gtf2i^tm1Vcam page

Embryonic abnormalities and craniofacial dysmorphology in Gtf2i^tm1Vcam/Gtf2i^tm1Vcam mutant mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204278
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A lox511 site and neomycin resistance cassette replaced part of intron 1, exon 2, which contains the ATG translation initiation codon, and part of intron 2. (J:204278)

Generation of the Gtf2i^tm1Vcam allele

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gtf2i Mutation: 139 strains or lines available

References

• Original: J:204278 Lucena J, et al., Essential role of the N-terminal region of TFII-I in viability and behavior. BMC Med Genet. 2010;11:61
• All: 4 reference(s)