Kmt2b^m1H
Chemically induced Allele Detail

Summary

• Symbol: Kmt2b^m1H
• Name: lysine (K)-specific methyltransferase 2B; mutation 1, Harwell
• MGI ID: MGI:5532298
• Synonyms: Mll2^F2648I
• Gene: Kmt2b Location: Chr7:30268283-30288151 bp, - strand Genetic Position: Chr7, 18.63 cM, cytoband A3
• Alliance: Kmt2b^m1H page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation that results in the amino acid substitution of phenylalanine with isoleucine at position 2648 (p.F2648I). (J:203736)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2b Mutation: 65 strains or lines available

References

• Original: J:203736 Goldsworthy M, et al., Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One. 2013;8(6):e61870
• All: 1 reference(s)