Ubr4^tm1.1Nkt
Targeted Allele Detail

Summary

• Symbol: Ubr4^tm1.1Nkt
• Name: ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.1, Yoshihiro Nakatani
• MGI ID: MGI:5532331
• Synonyms: p600^-
• Gene: Ubr4 Location: Chr4:139107970-139216844 bp, + strand Genetic Position: Chr4, 70.66 cM
• Alliance: Ubr4^tm1.1Nkt page

Growth retardation in E9.5-E12.5 Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203460
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neomycin resistance cassette and exon 1. (J:203460)

Generation of the Ubr4^tm1.1Nkt allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr4 Mutation: 247 strains or lines available

References

• Original: J:203460 Nakaya T, et al., p600 Plays Essential Roles in Fetal Development. PLoS One. 2013;8(6):e66269
• All: 1 reference(s)