Stra6^tm2.1Nbg
Targeted Allele Detail

Summary

• Symbol: Stra6^tm2.1Nbg
• Name: stimulated by retinoic acid gene 6; targeted mutation 2.1, Norbert B Ghyselinck
• MGI ID: MGI:5532504
• Synonyms: Stra6^L2
• Gene: Stra6 Location: Chr9:57971071-58061279 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband C
• Alliance: Stra6^tm2.1Nbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203449
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette and left exons 5 through 7 floxed. This allele was used to generated Stra6^tm1. (J:203449)

Generation of the Stra6^tm2.1Nbg and Stra6^tm1Nbg alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stra6 Mutation: 50 strains or lines available

References

• Original: J:203449 Berry DC, et al., The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013 Aug 23;288(34):24528-39
• All: 1 reference(s)