Coq7^tm2Hek
Targeted Allele Detail

Summary

• Symbol: Coq7^tm2Hek
• Name: demethyl-Q 7; targeted mutation 2, Siegfried Hekimi
• MGI ID: MGI:5532527
• Synonyms: Mclk1^loxP
• Gene: Coq7 Location: Chr7:118108881-118132529 bp, - strand Genetic Position: Chr7, 63.44 cM
• Alliance: Coq7^tm2Hek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202240
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 2. Another loxP site was inserted downstream of exon 3. (J:202240)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coq7 Mutation: 29 strains or lines available

References

• Original: J:202240 Wang Y, et al., Mitochondrial respiration without ubiquinone biosynthesis. Hum Mol Genet. 2013 Dec 1;22(23):4768-83
• All: 2 reference(s)