Tg(Penk-cre,-lacZ)1Mini
Transgene Detail

Summary

• Symbol: Tg(Penk-cre,-lacZ)1Mini
• Name: transgene insertion 1, Liliana Minichiello
• MGI ID: MGI:5532538
• Synonyms: BAC-Penk-Cre^tg
• Transgene: Tg(Penk-cre,-lacZ)1Mini Location: unknown
• Alliance: Tg(Penk-cre,-lacZ)1Mini page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Penk-cre,-lacZ)1Mini expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Penk (MGI:104629)

• Mutation details: BAC clone RP24-289D15 was modified by ET recombineering to insert a cassette with a hybrid intron, cre recombinase, an IRES site and the beta-galactosidase sequence (lacZ), along with an FRT-flanked neomycin/kanamycin selection marker, into the ATG site of the first coding exon of pre-proenkephalin (Penk). The selection marker was removed using Flp recombinase. The modified circular BAC was purified and verified by sequencing, before injection into oocytes. Founder information is not available. (J:204429)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Penk (mouse) Summary of all recombinase alleles driven by Penk. Alliance mouse Penk gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:204429 Besusso D, et al., BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior. Nat Commun. 2013;4:2031
• All: 1 reference(s)