Cxcr2^tm1Rmra
Targeted Allele Detail

Summary

• Symbol: Cxcr2^tm1Rmra
• Name: C-X-C motif chemokine receptor 2; targeted mutation 1, Richard Ransohoff
• MGI ID: MGI:5532705
• Synonyms: Cxcr2^fl
• Gene: Cxcr2 Location: Chr1:74193153-74200405 bp, + strand Genetic Position: Chr1, 38.41 cM
• Alliance: Cxcr2^tm1Rmra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204482
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:204482)

Generation of the Cxcr2^tm1Rmra allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr2 Mutation: 30 strains or lines available

References

• Original: J:204482 Liu L, et al., Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2. Genesis. 2013 Aug;51(8):587-95
• All: 13 reference(s)