Elovl1^tm1.1Akih
Targeted Allele Detail

Summary

• Symbol: Elovl1^tm1.1Akih
• Name: ELOVL fatty acid elongase 1; targeted mutation 1.1, Akio Kihara
• MGI ID: MGI:5532707
• Gene: Elovl1 Location: Chr4:118285321-118290150 bp, + strand Genetic Position: Chr4, 54.61 cM
• Alliance: Elovl1^tm1.1Akih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204477
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 8. Cre-mediated recombination removed exons 2 through 8 and left the FRT-flanked neomycin resistance cassette intact. Fatty acid elongation activity towards C22-CoA is greatly reduced in the skin, brain and liver. (J:204477)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elovl1 Mutation: 23 strains or lines available

References

• Original: J:204477 Sassa T, et al., Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol. 2013 Jul;33(14):2787-96
• All: 5 reference(s)