Sidt2^tm1.1Hzha
Targeted Allele Detail

Summary

• Symbol: Sidt2^tm1.1Hzha
• Name: SID1 transmembrane family, member 2; targeted mutation 1.1, Huiwen Zhang
• MGI ID: MGI:5532825
• Gene: Sidt2 Location: Chr9:45849155-45866556 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sidt2^tm1.1Hzha page

Increase in body size of Sidt2^tm1.1Hzha/Sidt2^tm1.1Hzha adult mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204228
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2, but left the FRT-flanked neomycin resistance cassette intact. Western blot analysis confirmed decreased protein expression in the liver. (J:204228)

Generation of the Sidt2^tm1.1Hzha allele

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sidt2 Mutation: 49 strains or lines available

References

• Original: J:204228 Gao J, et al., Impaired glucose tolerance in a mouse model of sidt2 deficiency. PLoS One. 2013;8(6):e66139
• All: 4 reference(s)