Mapk7^tm1.1Ctr
Targeted Allele Detail

Summary

• Symbol: Mapk7^tm1.1Ctr
• Name: mitogen-activated protein kinase 7; targeted mutation 1.1, Cathy Tournier
• MGI ID: MGI:5538262
• Synonyms: erk5loxP
• Gene: Mapk7 Location: Chr11:61379638-61385101 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Mapk7^tm1.1Ctr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132253
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:132253)

Tumor Data

List all tumor models in MMHCdb carrying Mapk7^tm1.1Ctr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk7 Mutation: 32 strains or lines available

References

• Original: J:132253 Wang X, et al., Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress. Cell Death Differ. 2006 Dec;13(12):2099-108
• All: 24 reference(s)