Ank3^tm2.1Bnt
Targeted Allele Detail

Summary

• Symbol: Ank3^tm2.1Bnt
• Name: ankyrin 3, epithelial; targeted mutation 2.1, Vann Bennett
• MGI ID: MGI:5538265
• Synonyms: AnkG^fl
• Gene: Ank3 Location: Chr10:69234608-69863266 bp, + strand Genetic Position: Chr10, 36.1 cM
• Alliance: Ank3^tm2.1Bnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198370
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 22. An FRT-flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 23. Flp-mediated recombination removed the neomycin resistance cassette and left exons 22 and 23 floxed. (J:198370)

Schematic of the Ank3^tm2.1Bnt and Ank3^tm2.2Bnt alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ank3 Mutation: 170 strains or lines available

References

• Original: J:198370 Jenkins PM, et al., E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. J Biol Chem. 2013 May 17;288(20):14018-31
• All: 18 reference(s)