Lhcgr^tm1.1Pnara
Targeted Allele Detail

Summary

• Symbol: Lhcgr^tm1.1Pnara
• Name: luteinizing hormone/choriogonadotropin receptor; targeted mutation 1.1, Prema Narayan
• MGI ID: MGI:5538310
• Synonyms: KiLHR^D582G
• Gene: Lhcgr Location: Chr17:89023909-89099418 bp, - strand Genetic Position: Chr17, 58.35 cM
• Alliance: Lhcgr^tm1.1Pnara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203295
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (GAC to GGA) in exon 11 result in the amino acid substitution of glycine for aspartic acid at position 582 (D582G). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:203295)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhcgr Mutation: 43 strains or lines available

References

• Original: J:203295 McGee SR, et al., Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene. Endocrinology. 2013 Oct;154(10):3900-13
• All: 4 reference(s)