Slc12a2^K842*
Spontaneous Allele Detail

Summary

• Symbol: Slc12a2^K842*
• Name: solute carrier family 12, member 2; Lys842Stop
• MGI ID: MGI:5538334
• Gene: Slc12a2 Location: Chr18:58011750-58079893 bp, + strand Genetic Position: Chr18, 32.15 cM
• Alliance: Slc12a2^K842* page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: An A-to-T transversion in exon 17 changes the lysine (K) at codon 842 into a stop codon. Western blot analysis of whole brain tissue confirmed the absence of protein expression in homozygous mice. This mutation arose in a strain carrying the Tg(Nes-cre/ERT2)1Fsh transgene. (J:201156)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a2 Mutation: 58 strains or lines available

References

• Original: J:201156 Antoine MW, et al., A causative link between inner ear defects and long-term striatal dysfunction. Science. 2013 Sep 6;341(6150):1120-3
• All: 3 reference(s)