Slc12a2^tm1.1Jheb
Targeted Allele Detail

Summary

• Symbol: Slc12a2^tm1.1Jheb
• Name: solute carrier family 12, member 2; targeted mutation 1.1, Jean M Hebert
• MGI ID: MGI:5538339
• Synonyms: NKCC1^flox, Slc12a2^fx
• Gene: Slc12a2 Location: Chr18:58011750-58079893 bp, + strand Genetic Position: Chr18, 32.15 cM
• Alliance: Slc12a2^tm1.1Jheb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201156
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 8 through 10 were flanked with loxP sites through homologous and cre-mediated recombination. (J:201156)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a2 Mutation: 58 strains or lines available

References

• Original: J:201156 Antoine MW, et al., A causative link between inner ear defects and long-term striatal dysfunction. Science. 2013 Sep 6;341(6150):1120-3
• All: 8 reference(s)