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Jak2tm2.2Jlvl
Targeted Allele Detail
Summary
Symbol: Jak2tm2.2Jlvl
Name: Janus kinase 2; targeted mutation 2.2, Jean-Luc Villeval
MGI ID: MGI:5538399
Synonyms: JAK2V617F, JAK2VF
Gene: Jak2  Location: Chr19:29229228-29290480 bp, + strand  Genetic Position: Chr19, 23.73 cM
Alliance: Jak2tm2.2Jlvl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202234
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA loxP site was inserted upstream of exon 13. A lox511 site, a inverted and modified exon 13 with a point mutation (GTC to TTC) that results in the amino acid substitution of phenylalanine for valine at position 617 (V617F) and a loxP site were inserted downstream of of exon 13. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 13 and left a lox511 site downstream of the modified exon 13. Cre-mediated recombination inverted the modified and endogenous exon 13 to allow for expression of the modified exon 13. (J:202234)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  59 strains or lines available
References
Original:  J:202234 Hasan S, et al., JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNalpha. Blood. 2013 Aug 22;122(8):1464-77
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory