Jak2tm2.2Jlvl
Targeted Allele Detail
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Symbol: |
Jak2tm2.2Jlvl |
Name: |
Janus kinase 2; targeted mutation 2.2, Jean-Luc Villeval |
MGI ID: |
MGI:5538399 |
Synonyms: |
JAK2V617F, JAK2VF |
Gene: |
Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
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Alliance: |
Jak2tm2.2Jlvl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:202234
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: A loxP site was inserted upstream of exon 13. A lox511 site, a inverted and modified exon 13 with a point mutation (GTC to TTC) that results in the amino acid substitution of phenylalanine for valine at position 617 (V617F) and a loxP site were inserted downstream of of exon 13. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 13 and left a lox511 site downstream of the modified exon 13. Cre-mediated recombination inverted the modified and endogenous exon 13 to allow for expression of the modified exon 13.
(J:202234)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Jak2 Mutation: |
59 strains or lines available
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Original: |
J:202234 Hasan S, et al., JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNalpha. Blood. 2013 Aug 22;122(8):1464-77 |
All: |
9 reference(s) |
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