Cyp2f2^tm1Ding
Targeted Allele Detail

Summary

• Symbol: Cyp2f2^tm1Ding
• Name: cytochrome P450, family 2, subfamily f, polypeptide 2; targeted mutation 1, Xinxin Ding
• MGI ID: MGI:5538527
• Gene: Cyp2f2 Location: Chr7:26819380-26833085 bp, + strand Genetic Position: Chr7, 15.82 cM
• Alliance: Cyp2f2^tm1Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204727
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 3' loxP site replaced exon 4 (coding exon 3). Western blot analysis confirmed the absence of protein expression in the liver, lung and nasal olfactory mucosa. (J:204727)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cyp2f2 Mutation: 33 strains or lines available

References

• Original: J:204727 Li L, et al., Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J Pharmacol Exp Ther. 2011 Oct;339(1):62-71
• All: 6 reference(s)