Marco^tm1Spt
Targeted Allele Detail

Summary

• Symbol: Marco^tm1Spt
• Name: macrophage receptor with collagenous structure; targeted mutation 1, Shari Pilon-Thomas
• MGI ID: MGI:5538543
• Gene: Marco Location: Chr1:120402267-120432753 bp, - strand Genetic Position: Chr1, 52.71 cM, cytoband E4-F
• Alliance: Marco^tm1Spt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exons 16 and 17. Immunohistochemistry confirmed the absence of protein expression in dendritic cells. (J:204315)

Generation of the Marco^tm1Spt allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marco Mutation: 38 strains or lines available

References

• Original: J:204315 Komine H, et al., Examination of MARCO activity on dendritic cell phenotype and function using a gene knockout mouse. PLoS One. 2013;8(7):e67795
• All: 1 reference(s)