Spo11^tm1.1Gvpc
Targeted Allele Detail

Summary

• Symbol: Spo11^tm1.1Gvpc
• Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1.1, Galina Petukhova
• MGI ID: MGI:5538688
• Synonyms: Spo11^Gal4
• Gene: Spo11 Location: Chr2:172819493-172835369 bp, + strand Genetic Position: Chr2, 95.64 cM, cytoband H4
• Alliance: Spo11^tm1.1Gvpc page

Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice and absence of ovarian follicles in Spo11^tm1.1Gvpc/Spo11^tm3Rdco mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202231
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Hypomorph) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 and 2 were replaced with a cDNA containing a GAL4 DNA binding domain. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted into the cDNA downstream of the GAL4 DNA binding domain. This allele is hypomorphic. (J:202231)

Generation of the Spo11^tm1.1Gvpc allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spo11 Mutation: 21 strains or lines available

References

• Original: J:202231 Smagulova F, et al., Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele. BMC Genomics. 2013;14:493
• All: 1 reference(s)