Sgo1^{Gt(neo-btk)1Dai}
Gene trapped Allele Detail

Summary

• Symbol: Sgo1^{Gt(neo-btk)1Dai}
• Name: shugoshin 1; gene trap 1, Wei Dai
• MGI ID: MGI:5543407
• Synonyms: SGO1^-
• Gene: Sgo1 Location: Chr17:53981814-53996361 bp, - strand Genetic Position: Chr17, 27.92 cM
• Alliance: Sgo1^{Gt(neo-btk)1Dai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204810
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: This gene trap vector includes a 5' viral long-terminal repeat, splice acceptor, neomycin resistance cassette, poly adenylation sequence, PGK promoter, Bruton tyrosine kinase coding sequence, splice donor and 3' viral long-terminal repeat. The vector inserted between exons 1 and 2 of the endogenous gene. Western blot analysis indicates an approximately 50% reduction of protein in heterozygotes. (J:204809)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgo1 Mutation: 29 strains or lines available

References

• Original: J:204810 Wang X, et al., sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell. 2008 Mar;14(3):331-41
• All: 6 reference(s)