Siglecf^tm1.2Avrk
Targeted Allele Detail

Summary

• Symbol: Siglecf^tm1.2Avrk
• Name: sialic acid binding Ig-like lectin F; targeted mutation 1.2, Ajit Varki
• MGI ID: MGI:5543479
• Gene: Siglecf Location: Chr7:43000765-43008955 bp, + strand Genetic Position: Chr7, 28.25 cM, cytoband B3
• Alliance: Siglecf^tm1.2Avrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204811
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the floxed exons 1 through 3. This allele lacks the neomycin resistance cassette. Flow cytometry confirmed the absence of protein expression on peripheral blood leukocytes. (J:204811)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Siglecf Mutation: 58 strains or lines available

References

• Original: J:204811 Zhang M, et al., Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 2007 May 15;109(10):4280-7
• All: 3 reference(s)