Car7^tm1.1Kkai
Targeted Allele Detail

Summary

• Symbol: Car7^tm1.1Kkai
• Name: carbonic anhydrase 7; targeted mutation 1.1, Kai Kaila
• MGI ID: MGI:5543604
• Gene: Car7 Location: Chr8:105261326-105276979 bp, + strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Car7^tm1.1Kkai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200079
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed the neomycin resistance cassette and exons 5 through 7. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:200079)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Car7 Mutation: 17 strains or lines available

References

• Original: J:200079 Ruusuvuori E, et al., Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32(16):2275-86
• All: 2 reference(s)