Rock1^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Rock1^tm1.1Itl
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5543630
• Synonyms: ROCK1^flox
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204885
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin resistance cassette and left exon 5 floxed. (J:204885)

Generation of the Rock1^tm1.1Itl and Rock1^tm1.2Itl alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 60 strains or lines available

References

• Original: J:204885 Huang H, et al., Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012 Oct;15(10):1391-8
• All: 7 reference(s)