Rasip1^tm1.1Wye
Targeted Allele Detail

Summary

• Symbol: Rasip1^tm1.1Wye
• Name: Ras interacting protein 1; targeted mutation 1.1, Weilan Ye
• MGI ID: MGI:5543662
• Gene: Rasip1 Location: Chr7:45276961-45288516 bp, + strand Genetic Position: Chr7, 29.39 cM
• Alliance: Rasip1^tm1.1Wye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203698
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT and loxP site were inserted downstream of exon 3. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in E9.5 embryos. (J:203698)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasip1 Mutation: 31 strains or lines available

References

• Original: J:203698 Wilson CW, et al., Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling. Blood. 2013 Nov 21;122(22):3678-90
• All: 1 reference(s)